Hate (1990) #2

“Hate at First Sight” introduces Buddy Bradley’s extremely neurotic, quick-to-anger girlfriend Valerie (who he ends up sleeping with in a hospital bed, of all places), along with her weird roommate Lisa. Buddy’s pathetic physique, George’s nebbish behavior, and Stinky’s increasingly obnoxious ways are all on display, further cementing these characters as hopeless losers.

Fantagraphics. Written and drawn by Peter Bagge. (Note: reference picture, not an actual scan)